Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.4
USERS' SCORE
Good
Based on 22 Reviews
8.4
Supplement Facts
Serving Size: 1 Veggie Capsule
Serving Per Container: 90
Amount Per Serving
%DV
Nattokinase(from fibrinase enzyme)
2,000 FU**
†
Top Medical Research Studies
9
Nattokinase shows strong clot-busting activity
We explored the effectiveness of nattokinase, a natural enzyme known for its role in breaking down blood clots, by studying its production and activity in a lab setting. Nattokinase was extracted from Bacillus subtilis, and we introduced this gene into E. coli bacteria to produce the enzyme at high levels.
Through our process, we purified the active recombinant nattokinase and tested its ability to dissolve blood clots. Our results were promising; the enzyme exhibited a fibrinolytic activity of 58FU/mg, which is notably five times more effective than the currently used drug, orokinase.
We optimized the conditions for producing nattokinase, including factors like temperature and nutrient concentrations, resulting in an impressive yield of 1805.50 mg/L. This improved production method paves the way for scaling up nattokinase's use in treating cardiovascular diseases related to blood clots. The findings emphasize nattokinase's potential as an effective thrombolytic agent.
Through our process, we purified the active recombinant nattokinase and tested its ability to dissolve blood clots. Our results were promising; the enzyme exhibited a fibrinolytic activity of 58FU/mg, which is notably five times more effective than the currently used drug, orokinase.
We optimized the conditions for producing nattokinase, including factors like temperature and nutrient concentrations, resulting in an impressive yield of 1805.50 mg/L. This improved production method paves the way for scaling up nattokinase's use in treating cardiovascular diseases related to blood clots. The findings emphasize nattokinase's potential as an effective thrombolytic agent.
Read More
9
We explored the fascinating impact of nattokinase, a natural enzyme known for its blood-thinning properties, particularly its effect on blood clots. In our investigation, we examined how nattokinase interacts with thrombin, a key protein involved in the clotting process, and identified this enzyme as a significant substrate for nattokinase.
By employing a stepwise computational strategy, we modeled the interactions between nattokinase and thrombin to pinpoint specific cleavage sites. This innovative approach allowed us to validate our predictions through mass spectrometry and functional assays, solidifying our understanding of how nattokinase works at a molecular level.
Our findings reveal that nattokinase might play a vital role in breaking the cycle of inflammation and thrombosis by targeting thrombin, thus enhancing its therapeutic potential for cardiovascular health. Overall, this study sheds light on the crucial interactions between these proteins and underscores the importance of nattokinase in managing blood clot dynamics.
By employing a stepwise computational strategy, we modeled the interactions between nattokinase and thrombin to pinpoint specific cleavage sites. This innovative approach allowed us to validate our predictions through mass spectrometry and functional assays, solidifying our understanding of how nattokinase works at a molecular level.
Our findings reveal that nattokinase might play a vital role in breaking the cycle of inflammation and thrombosis by targeting thrombin, thus enhancing its therapeutic potential for cardiovascular health. Overall, this study sheds light on the crucial interactions between these proteins and underscores the importance of nattokinase in managing blood clot dynamics.
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9
We aimed to explore how nattokinase, a key enzyme in natto—a traditional Japanese fermented soy product—affects blood clots. Our focus was on a newly isolated strain from Indonesian natto, named G8, which showed promising fibrinolytic activity, meaning its ability to dissolve blood clots.
Through various fibrinolytic assays, we discovered that both nattokinase and G8 could effectively dissolve clots from whole blood and euglobulin, indicating their potential in managing vascular obstructive diseases. A closer look at G8 revealed that it can directly break down fibrin, which is crucial in clot formation.
Interestingly, the crude extract of G8 demonstrated six distinct bands of activity on zymography, with the most potent activity found at a molecular weight of 20.0 kDa. This suggests that G8 contains a variety of fibrinolytic enzymes, potentially including nattokinase and others that support its clot-dissolving abilities. In summary, we observed that G8 exhibits strong fibrinolytic properties, supported by multiple enzymes working together to aid in clot dissolution.
Through various fibrinolytic assays, we discovered that both nattokinase and G8 could effectively dissolve clots from whole blood and euglobulin, indicating their potential in managing vascular obstructive diseases. A closer look at G8 revealed that it can directly break down fibrin, which is crucial in clot formation.
Interestingly, the crude extract of G8 demonstrated six distinct bands of activity on zymography, with the most potent activity found at a molecular weight of 20.0 kDa. This suggests that G8 contains a variety of fibrinolytic enzymes, potentially including nattokinase and others that support its clot-dissolving abilities. In summary, we observed that G8 exhibits strong fibrinolytic properties, supported by multiple enzymes working together to aid in clot dissolution.
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Most Useful Reviews
10
Life-saving product
316 people found this helpful
This could save your life! I love this nattokinase and believe everyone should be taking it. It could literally save your life! The nattozymes dissolve a blood clot on contact. Many years ago, a Japanese scientist discovered this by accident. After years of trying everything, I tried this product, and the next day was the best day I've had in ages—full of energy, no pain, and my blood pressure was perfect.
Read More
10
Replaced Coumadin effectively
62 people found this helpful
Good replacement for Coumadin. After being hospitalised for a blood clot in my leg, my doctor prescribed Lovenox and Coumadin. The dosing was erratic, leading to memory loss and painful nodules from injections. After researching, I found this product, and after two weeks, my INR was stable, prompting me to discontinue other medications. My doctor was evidently displeased but could not dispute the positive results. I feel great, no memory issues, and my stomach has healed, with blood clots disappearing.
Read More
10
Saved my pregnancy
57 people found this helpful
Saved my lung, leg, and allowed me to have my daughter. I have a blood clotting disorder known as antiphospholipid syndrome. After two miscarriages because of blood clots, I treated myself with nattokinase and serrapeptase, alongside ginger and turmeric. Immediately after starting the capsules, small blood clots in my hands disappeared, as did a pain in my lung and discomfort in my leg where I experienced a DVT after my first miscarriage. With the help of these natural blood thinners, I was able to have my daughter safely. I believe science and nature together are essential; this supplement was my lifesaver.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.4
- All Researches
9
We explored the impact of nattokinase, a natural enzyme known for breaking down blood clots, particularly in the context of acute myocardial infarction (MI), a serious heart condition often caused by these clots. The study investigated a special formulation combining nattokinase with a manganese oxide nanozyme, designed to enhance its effectiveness and stability.
Through tail vein injections into a mouse model, the combination of manganese oxide and nattokinase showed promising results. We observed that this innovative treatment not only helped dissolve clots but also countered oxidative stress—an issue that often exacerbates heart damage. The results indicated significant improvements in restoring blood flow and reducing heart injury.
Overall, our findings suggest that this nattokinase-loaded nanozyme could represent a valuable new tool in treating acute MI, potentially paving the way for better therapeutic strategies in the clinical setting.
Through tail vein injections into a mouse model, the combination of manganese oxide and nattokinase showed promising results. We observed that this innovative treatment not only helped dissolve clots but also countered oxidative stress—an issue that often exacerbates heart damage. The results indicated significant improvements in restoring blood flow and reducing heart injury.
Overall, our findings suggest that this nattokinase-loaded nanozyme could represent a valuable new tool in treating acute MI, potentially paving the way for better therapeutic strategies in the clinical setting.
Read More
9
We explored the effectiveness of a novel treatment combining nattokinase with magnetic vortex nanorobots for tackling blood clots. The study cleverly used these tiny robots, which are about 70 nanometers in size, powered by dual-frequency magnetic fields to improve drug delivery and enhance the effects of nattokinase.
By assembling into chain-like formations, these nanorobots can navigate through microvascular systems and directly target clots, creating mechanical forces to disrupt them efficiently. The combination of a low-frequency rotating field and a high-frequency alternating field helped not only to penetrate the thrombus but also to release nattokinase effectively.
Our findings revealed that this innovative approach, termed dual frequency-regulated magnetothrombolysis, achieved an impressive vasculature recanalization rate of 81.0% in thrombotic mice. This suggests that enhancing the therapeutic qualities of nattokinase with advanced nanotechnology represents a promising pathway for resolving blood clots more effectively.
By assembling into chain-like formations, these nanorobots can navigate through microvascular systems and directly target clots, creating mechanical forces to disrupt them efficiently. The combination of a low-frequency rotating field and a high-frequency alternating field helped not only to penetrate the thrombus but also to release nattokinase effectively.
Our findings revealed that this innovative approach, termed dual frequency-regulated magnetothrombolysis, achieved an impressive vasculature recanalization rate of 81.0% in thrombotic mice. This suggests that enhancing the therapeutic qualities of nattokinase with advanced nanotechnology represents a promising pathway for resolving blood clots more effectively.
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9
We explored how a combination of nattokinase (NK) and heparin (HP) can tackle cancer-related thrombosis (CAT), a common issue in cancer patients that can worsen their condition and quality of life. In our approach, we developed an electrostatic complex of these two agents to mitigate the toxicity typically associated with intravenous NK administration.
Our findings were quite promising. We observed that this NK-HP complex not only addressed the toxicity of NK but also demonstrated strong abilities to break down blood clots. The combination therapy was able to prevent new thrombosis from forming, significantly aiding its use in advanced tumors. Additionally, we found that administering NK-HP alongside specially formulated doxorubicin liposomes enhanced the treatment's effectiveness. This improvement was attributed to reduced fibrin levels in tumors and increased breakdown products, pointing to successful clot dissolution.
Importantly, our work highlights a potential breakthrough in managing CAT in cancer treatment, suggesting that our NK-HP method could be an effective strategy for improving outcomes in patients facing advanced tumors.
Our findings were quite promising. We observed that this NK-HP complex not only addressed the toxicity of NK but also demonstrated strong abilities to break down blood clots. The combination therapy was able to prevent new thrombosis from forming, significantly aiding its use in advanced tumors. Additionally, we found that administering NK-HP alongside specially formulated doxorubicin liposomes enhanced the treatment's effectiveness. This improvement was attributed to reduced fibrin levels in tumors and increased breakdown products, pointing to successful clot dissolution.
Importantly, our work highlights a potential breakthrough in managing CAT in cancer treatment, suggesting that our NK-HP method could be an effective strategy for improving outcomes in patients facing advanced tumors.
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9
We explored the effectiveness of nattokinase in helping dissolve blood clots while also addressing inflammation. The study successfully created amphiphilic block polymer-based nanovesicles that release both the anti-inflammatory drug indomethacin and nattokinase specifically at sites where reactive oxygen species (ROS) are plentiful—like inflamed or thrombotic tissues.
The combination of these drugs is significant; however, evaluating nattokinase's isolated effect is complex due to its combined use with indomethacin. The dual-action nanovesicles showed promising results in a mouse model of thrombosis, enhancing treatment outcomes by quickening the release of both drugs in response to inflammatory conditions.
Despite the potential of nattokinase, the findings indicate that its effect cannot be isolated from that of indomethacin, making it difficult to assess its individual contribution to thrombolytic success.
The combination of these drugs is significant; however, evaluating nattokinase's isolated effect is complex due to its combined use with indomethacin. The dual-action nanovesicles showed promising results in a mouse model of thrombosis, enhancing treatment outcomes by quickening the release of both drugs in response to inflammatory conditions.
Despite the potential of nattokinase, the findings indicate that its effect cannot be isolated from that of indomethacin, making it difficult to assess its individual contribution to thrombolytic success.
Read More
9
Nattokinase shows strong clot-busting activity
We explored the effectiveness of nattokinase, a natural enzyme known for its role in breaking down blood clots, by studying its production and activity in a lab setting. Nattokinase was extracted from Bacillus subtilis, and we introduced this gene into E. coli bacteria to produce the enzyme at high levels.
Through our process, we purified the active recombinant nattokinase and tested its ability to dissolve blood clots. Our results were promising; the enzyme exhibited a fibrinolytic activity of 58FU/mg, which is notably five times more effective than the currently used drug, orokinase.
We optimized the conditions for producing nattokinase, including factors like temperature and nutrient concentrations, resulting in an impressive yield of 1805.50 mg/L. This improved production method paves the way for scaling up nattokinase's use in treating cardiovascular diseases related to blood clots. The findings emphasize nattokinase's potential as an effective thrombolytic agent.
Through our process, we purified the active recombinant nattokinase and tested its ability to dissolve blood clots. Our results were promising; the enzyme exhibited a fibrinolytic activity of 58FU/mg, which is notably five times more effective than the currently used drug, orokinase.
We optimized the conditions for producing nattokinase, including factors like temperature and nutrient concentrations, resulting in an impressive yield of 1805.50 mg/L. This improved production method paves the way for scaling up nattokinase's use in treating cardiovascular diseases related to blood clots. The findings emphasize nattokinase's potential as an effective thrombolytic agent.
Read More
User Reviews
USERS' SCORE
Good
Based on 22 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
10
Life-saving product
316 people found this helpful
This could save your life! I love this nattokinase and believe everyone should be taking it. It could literally save your life! The nattozymes dissolve a blood clot on contact. Many years ago, a Japanese scientist discovered this by accident. After years of trying everything, I tried this product, and the next day was the best day I've had in ages—full of energy, no pain, and my blood pressure was perfect.
Read More
10
Replaced Coumadin effectively
62 people found this helpful
Good replacement for Coumadin. After being hospitalised for a blood clot in my leg, my doctor prescribed Lovenox and Coumadin. The dosing was erratic, leading to memory loss and painful nodules from injections. After researching, I found this product, and after two weeks, my INR was stable, prompting me to discontinue other medications. My doctor was evidently displeased but could not dispute the positive results. I feel great, no memory issues, and my stomach has healed, with blood clots disappearing.
Read More
10
Saved my pregnancy
57 people found this helpful
Saved my lung, leg, and allowed me to have my daughter. I have a blood clotting disorder known as antiphospholipid syndrome. After two miscarriages because of blood clots, I treated myself with nattokinase and serrapeptase, alongside ginger and turmeric. Immediately after starting the capsules, small blood clots in my hands disappeared, as did a pain in my lung and discomfort in my leg where I experienced a DVT after my first miscarriage. With the help of these natural blood thinners, I was able to have my daughter safely. I believe science and nature together are essential; this supplement was my lifesaver.
Read More
9
Improved knee pain
50 people found this helpful
Excellent product. It all began with my troublesome knee; after an X-ray, the doctor informed me of mild arthritis and suggested a cortisone injection, assuring me it would help. However, the pain worsened, leading to a recommendation for surgery, which I found hard to believe. I searched for natural remedies and discovered Nattokinase and Serrapeptase. After less than two months of taking them, my knee pain has entirely vanished along with the heaviness and numbness on the opposite side. When on my feet for extended periods, I still feel some discomfort, but it's nothing compared to before. Additionally, my heart rate has normalised, and I have Atrial fibrillation. To prevent blood clots, my cardiologist prescribed Pradaxa, yet I found that my heart feels better than ever. The discolouration on my legs due to small veins has also improved. I'm delighted with these results and have recommended Nattokinase and Serrapeptase to friends and family.
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7.5
Natural alternative
47 people found this helpful
I believe everyone of mature age should take this! After a severe AFib attack, the doctors insisted I take blood thinners. Instead, I replaced them with natural alternatives like nattokinase. Research shows it helps keep blood thinner naturally and prevents it from clotting. I feel better shortly after taking it, and it has given me more energy. Many have switched to this from prescription blood thinners to avoid awful side effects. In my opinion, it's beneficial for health!
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Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Zhang Z, Gao F, Mao J, Liu J, Zeng Z, et al. Biophysiochemically favorable, antithrombotic and pro-endothelial coordination compound nanocoating of copper (II) with protocatechuic acid & nattokinase on flow-diverting stents. Colloids Surf B Biointerfaces. 2025;249:114509. doi:10.1016/j.colsurfb.2025.114509
- Shi Y, Liu C, Gui Y, Guo Y, Zhang Y, et al. A Nattokinase-Loaded Nanozyme for Alleviating Acute Myocardial Infarction via Thrombolysis and Antioxidation. Adv Healthc Mater. 2024. doi:10.1002/adhm.202402763
- Gao R, Zhang W, Chen X, Shen J, Qin Y, et al. Dual Frequency-Regulated Magnetic Vortex Nanorobots Empower Nattokinase for Focalized Microvascular Thrombolysis. ACS Nano. 2024;18:29492. doi:10.1021/acsnano.4c04331
- Wang D, Kou Y, Guo T, Duan L, Chen J, et al. Intravenous injection of nattokinase-heparin electrostatic complex improves the therapeutic effect of advanced tumors by dissolving cancer-related thrombosis. Life Sci. 2024;355:122935. doi:10.1016/j.lfs.2024.122935
- Coutinho SB, Shirodkar RR, Kanjirakkandy A, Arulmozhi V, Vaithilingam M, et al. Production of Nattokinase from MRS18: A Bacterial Strain Isolated from Fermented Beans. Cardiovasc Hematol Agents Med Chem. 2024;22:223. doi:10.2174/0118715257275639231219054353
- Feng H, Liu C, Liu Q, Wang J, Zeng Y, et al. Study on the transport and internalisation mechanism of dietary supplement nattokinase in the small intestine using animal and Caco-2 cell monolayer models. Xenobiotica. 2023;53:670. doi:10.1080/00498254.2023.2284249
- Xia Y, Chen R, Ke Y, Han Q, Ma Z, et al. ROS-responsive phenylboronic ester-based nanovesicles as multifunctional drug delivery systems for the treatment of inflammatory and thrombotic complications. Biomater Sci. 2023;11:7805. doi:10.1039/d3bm01427d
- Li Y, Chen L, Tang X, Zhu W, Ma A, et al. Combined Computer-Aided Predictors to Improve the Thermostability of Nattokinase. Foods. 2023;12. doi:10.3390/foods12163045
- Modi A, Raval I, Doshi P, Joshi M, Joshi C, et al. Heterologous expression of recombinant nattokinase in Escherichia coli BL21(DE3) and media optimization for overproduction of nattokinase using RSM. Protein Expr Purif. 2023;203:106198. doi:10.1016/j.pep.2022.106198
- Wang Y, Wang H, Zhang Y, Xu F, Wang J, et al. Stepwise Strategy to Identify Thrombin as a Hydrolytic Substrate for Nattokinase. J Chem Inf Model. 2022;62:5780. doi:10.1021/acs.jcim.2c00978
- Pinontoan R, Sanjaya A, Jo J. Fibrinolytic characteristics of G8 isolated from natto. Biosci Microbiota Food Health. 2021;40:144. doi:10.12938/bmfh.2020-071
- Zhang X, Tong Y, Wang J, Lyu X, Yang R. Screening of a Bacillus subtilis strain producing both nattokinase and milk-clotting enzyme and its application in fermented milk with thrombolytic activity. J Dairy Sci. 2021;104:9437. doi:10.3168/jds.2020-19756
- Gallelli G, Di Mizio G, Palleria C, Siniscalchi A, Rubino P, et al. Data Recorded in Real Life Support the Safety of Nattokinase in Patients with Vascular Diseases. Nutrients. 2021;13. doi:10.3390/nu13062031
- Liu S, Zhu J, Liu C, Li J, Li Z, et al. Synthesis of sustained release/controlled release nanoparticles carrying nattokinase and their application in thrombolysis. Pharmazie. 2021;76:145. doi:10.1691/ph.2021.0155
- Li X, Yang X, Umar M, Zhang Z, Luo W, et al. Expression of a novel dual-functional polypeptide and its pharmacological action research. Life Sci. 2021;267:118890. doi:10.1016/j.lfs.2020.118890
- Zhang X, Lyu X, Tong Y, Wang J, Ye J, et al. Chitosan/casein based microparticles with a bilayer shell-core structure for oral delivery of nattokinase. Food Funct. 2020;11:10799. doi:10.1039/d0fo02349c
- Liu M, Xu Z, Wang Z, Wang D, Yang M, et al. Lipid-lowering, antihypertensive, and antithrombotic effects of nattokinase combined with red yeast rice in patients with stable coronary artery disease: a randomized, double-blinded, placebo-controlled trial. Front Nutr. 2024;11:1380727. doi:10.3389/fnut.2024.1380727
- Takagaki S, Suzuki M, Suzuki E, Hasumi K. Unsaturated fatty acids enhance the fibrinolytic activity of subtilisin NAT (nattokinase). J Food Biochem. 2020;44:e13326. doi:10.1111/jfbc.13326
